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Drug Interactions With Oxycodone/APAP

More Information on Interactions With Oxycodone/APAP

The following sections explain in detail the potentially negative interactions that can occur when oxycodone/APAP is combined with any of the drugs listed above.
 
Alcohol
You should avoid alcohol while taking oxycodone/APAP. Alcohol interacts with the narcotic component of the drug (oxycodone), potentially increasing the risk of serious side effects, such as extreme drowsiness, confusion, memory loss, or difficulty breathing. Alcohol also interacts with the acetaminophen (Tylenol®) component, increasing the risk of liver damage (see Tylenol and Alcohol for more information).
 
Anticholinergics
Combining oxycodone/APAP with an anticholinergic medication increases the risk of constipation and dangerous intestinal blockages. It is best to check with your healthcare provider before combining these two medications, especially if you are not taking a stimulant laxative to prevent constipation.
 
Antidepressant Medications
Taking an antidepressant with oxycodone/APAP could increase your risk of side effects, such as drowsiness, confusion, memory loss, or difficulty breathing. Serious side effects may also occur. Talk to your healthcare provider before taking these medications together, as you may need to be monitored more closely and the dose of your medications may need to be adjusted.
 
Antihistamines
Many antihistamines cause significant drowsiness and can cause serious problems when used in combination with other medications that cause drowsiness, such as oxycodone/APAP. Check with your healthcare provider before taking oxycodone/APAP with an antihistamine, including non-prescription antihistamines.
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