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Precautions and Warnings With Oxaprozin

Specific Precautions and Warnings With Oxaprozin

Warnings and precautions to be aware of prior to taking oxaprozin include the following:
 
  • Certain medications can interact with oxaprozin (see Drug Interactions With Oxaprozin).
     
  • All NSAIDs, including oxaprozin, have been reported to cause cardiovascular events, such as heart attack or stroke, which can result in loss of life. People with cardiovascular disease or who have cardiovascular risk factors appear to be at greater risk. To decrease the chances of these problems occurring, you should take the smallest effective dose for the shortest period of time. Call 911 if you notice:
 
    • Chest pain
    • Shortness of breath
    • Weakness
    • Slurring of speech.
 
  • All NSAIDs, including oxaprozin, may cause high blood pressure or make it worse. Thus, oxaprozin should be used with caution in people with known high blood pressure.
     
  • All NSAIDs, including oxaprozin, may cause congestive heart failure or swelling. Contact your healthcare provider if you notice unexplained weight gain or swelling. Also, oxaprozin should be used with caution in people with heart failure.
     
  • All NSAIDs, including oxaprozin, have been reported to cause problems in the stomach and intestines, including bleeding (known as gastrointestinal bleeding), stomach ulcers, or holes in the stomach or intestines (called perforations). These problems can lead to serious complications or even loss of life. Therefore, extreme caution should be used if oxaprozin is prescribed for people with a history of ulcers or gastrointestinal bleeding. To decrease the chances of these problems occurring, you should take the smallest effective dose for the shortest period of time. Contact your healthcare provider immediately if you experience any signs of stomach ulcers or bleeding, including:
 
    • Stomach pain
    • Indigestion
    • Black, tarry stools
    • Vomiting blood.
 
  • Kidney damage can happen in people taking NSAIDs, including oxaprozin. It is more common in people with kidney disease, heart failure, liver problems, those taking diuretics or an ACE inhibitor, and the elderly.
     
  • Liver damage can happen with people who are taking oxaprozin. Contact your healthcare provider immediately if you notice:
 
    • Nausea
    • Tiredness
    • Lethargy
    • Itchy or yellowing skin
    • Abdominal pain
    • Flu-like symptoms.
 
  • NSAIDs, including oxaprozin, have been reported to cause allergic reactions. Seek emergency medical attention immediately if you notice things such as difficulty breathing and swelling of the face and throat.
     
  • In rare cases, people taking oxaprozin can develop a very serious rash. If you notice an unexplained rash or blisters, fever, or itchy skin, stop taking the oxaprozin and call your healthcare provider.
     
  • If you are an alcoholic or drink alcohol frequently, discuss this with your healthcare provider prior to starting oxaprozin. Alcohol can affect the way the liver works, indirectly affecting the way oxaprozin works.
     
  • NSAIDS have been known to cause an increase in liver enzymes. Therefore, you should have a blood test that looks at your liver function before starting oxaprozin and when again 12 weeks after treatment has started.
     
  • Oxaprozin may increase your sensitivity to the sun. Therefore, when going outdoors, try wearing long sleeves, pants, and a hat. Any exposed skin should be covered with sunscreen that is at least SPF 15.
     
  • Oxaprozin has been known to cause anemia. If you are taking oxaprozin for an extended amount of time and show signs of anemia, talk to your healthcare provider.
     
  • You should not take oxaprozin with any other NSAIDs, as this may increase your risk for any of the problems discussed in this article. Many NSAIDs are available without a prescription -- make sure to read labels carefully. Examples of NSAIDs include:
 
 
  • Oxaprozin is a pregnancy Category C medicine, meaning that the drug could potentially cause harm to your unborn child. If you are pregnant, you should only take oxaprozin if the benefit outweighs the possible risk to the fetus. Oxaprozin is not recommended for women in their third trimester of pregnancy because it can cause injury and even death to the developing fetus. If you become pregnant while taking oxaprozin, contact your healthcare provider immediately (see Daypro and Pregnancy).
     
  • If you are nursing, you should not take oxaprozin. Therefore, if you are taking oxaprozin, ask your healthcare provider whether to stop nursing or to discontinue the medicine.
     
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