Drug Interactions With Oxaprozin

If you take certain medicines together without first consulting your healthcare provider, it is possible to develop drug interactions. With oxaprozin, interactions with medications such as methotrexate, cyclosporine, or beta blockers may cause serious side effects. The effectiveness of the medications can also be decreased. Some drug interactions with oxaprozin can cause an increased risk of bleeding, kidney damage, or stomach ulcers.

Oxaprozin (Daypro)

Drug Interactions With Oxaprozin: An Introduction

Oxaprozin (Daypro^®) has a number of medicines that it can potentially interact with. Some of these drug interactions with oxaprozin include:

Warfarin (Coumadin^®, Jantoven^®)
Other nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen (Advil^®, Motrin^®), naproxen (Aleve^®, Anaprox^®, Naprosyn^®, Naprelan^®), diclofenac (Cataflam^®, Voltaren^®), indomethacin (Indocin^®), nabumetone (Relafen^®), piroxicam (Feldene^®), celecoxib (Celebrex^®), etodolac (Lodine^®, Lodine XL^®), meloxicam (Mobic^®), and others
Aspirin
Lithium (Eskalith^®, Lithane^®, Lithonate^®, Lithotabs^®)
Diuretics, such as torsemide (Demadex^®), furosemide (Lasix^®), and hydrochlorothiazide
ACE inhibitors, such as lisinopril (Zestril^®, Prinivil^®), fosinopril (Monopril^®), captopril (Capoten^®), quinapril (Accupril^®), benazepril (Lotensin^®), enalapril (Vasotec^®), and ramipril (Altace^®)
Methotrexate (Rheumatrex^®, Trexall™)
Cyclosporine (Gengraf^®, Neoral^®, Sandimmune^®)
Glyburide (Diabeta^®, Glynase^®, Micronase^®)
Beta blockers, such as metoprolol (Lopressor^®), ropanolol (Inderal^®), atenolol (Tenormin^®), and metoprolol (Toprol XL^®)
Corticosteroids, such as prednisone, hydrocortisone (Cortef^®), dexamethasone (Decadron^®, Dexone^®, Hexadrol^®), and many others.

Several herbal and nutritional supplements can also interact with oxaprozin and may increase the risk of bleeding. Examples of these include, but are not limited to:

Dong quai
Feverfew
Garlic
Ginger
Ginkgo biloba
Ginseng
St. John's wort
Fish oil supplements.

(Drug Interactions With Oxaprozin Continued: Page 2)