If you take certain medicines together without first consulting your healthcare provider, it is possible to develop drug interactions. With oxaprozin, interactions with medications such as methotrexate, cyclosporine, or beta blockers may cause serious side effects. The effectiveness of the medications can also be decreased. Some drug interactions with oxaprozin can cause an increased risk of bleeding, kidney damage, or stomach ulcers.
Corticosteroids, such as prednisone, hydrocortisone (Cortef®), dexamethasone (Decadron®, Dexone®, Hexadrol®), and many others.
Several herbal and nutritional supplements can also interact with oxaprozin and may increase the risk of bleeding. Examples of these include, but are not limited to: