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Opana ER Side Effects

It's hard to predict if you will develop side effects while taking Opana ER, but it is important to know that this prescription pain reliever can cause potentially serious problems that require medical treatment. Make sure to seek medical attention right away if you experience severe constipation, the urge to take the medication more often, or difficulty passing urine.

An Introduction to Opana ER Side Effects

Just like any medicine, Opana® ER (oxymorphone ER) can cause side effects. However, not everyone who takes the medication will experience problems. In fact, most people tolerate it quite well. If side effects do occur, in most cases, they are minor and either require no treatment or are treated easily by you or your healthcare provider.
(This article covers many, but not all, of the possible side effects with Opana ER. Your healthcare provider can discuss a more complete list with you.)

Common Side Effects of Opana ER

Opana ER has been studied extensively in clinical trials. Some of these studies compared Opana ER to a similar product that did not contain any active ingredients (a placebo).
In these studies, the most common Opana ER side effects included:
  • Nausea -- in up to 33 percent of people
  • Constipation (see Opana ER and Constipation) -- up to 28 percent
  • Drowsiness -- up to 19 percent
  • Dizziness -- up to 18 percent
  • Vomiting -- up to 16 percent
  • Itching -- up to 15 percent
  • Headache -- up to 12 percent.
Opioids like Opana ER can cause a release of histamine, resulting in itching unrelated to any allergy. If you develop itching but do not have any other allergy symptoms, it is unlikely that you are allergic to Opana ER. However, tell your healthcare provider if this side effect becomes bothersome, as there are medications available to help relieve the itching.
Other common reactions, occurring in 3 percent to 6 percent of people, included:
  • Dry mouth
  • Insomnia
  • Fatigue
  • Decreased appetite
  • Abdominal (stomach) pain.
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Opana ER Drug Information

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