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Opana ER Drug Interactions

Your healthcare provider needs to be aware of your alcohol consumption and whether you are taking any other medications or supplements before you can safely use Opana ER. Some of the drugs that can cause negative interactions with Opana ER include antidepressants, MAOIs, and sleep medications. Combining these medications may increase your risk for side effects, such as confusion, drowsiness, or difficulty breathing.

An Overview of Interactions With Opana ER

Opana® ER (oxymorphone ER) may react with a number of other medications. Some of the drugs that can lead to interactions with Opana ER include but are not limited to:
  • Alcoholic beverages
  • Alvimopan (Entereg®)
  • Antidepressants
  • Antihistamines (including many nonprescription cold, cough, allergy, motion sickness, and sleep medications)
  • Anticholinergic medications, such as:
  • Barbiturates, such as:
    • Amobarbital (Amytal®)
    • Butalbital (Fioricet®, Fiorinal®)
    • Pentobarbital (Nembutal®)
    • Phenobarbital (Luminal®)
    • Secobarbital (Seconal®)
  • Benzodiazepine sedatives, such as:
  • Muscle relaxants, such as:
  • Monoamine oxidase inhibitors (MAOIs), such as:
What Your Pharmacist Wishes You Knew About Chronic Pain Medications

Opana ER Drug Information

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