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Ofirmev Warnings and Precautions

Before receiving Ofirmev, let your healthcare provider know if you are breastfeeding or pregnant, or have any allergies. Other safety precautions with Ofirmev include warnings against using this medication if you have certain medical problems, such as liver disease, alcoholism, or severe dehydration. This medicine may also increase the risk for liver damage in some people.

What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to receiving Ofirmev™ (intravenous acetaminophen) if you have:
  • Liver disease, such as cirrhosis, liver failure, or hepatitis
  • Alcoholism
  • Kidney disease, such as kidney failure
  • Severe dehydration or excessive blood loss
  • Chronic malnutrition
  • Any allergies, including allergies to foods, dyes, or preservatives.
Also, let your healthcare provider know if you are:
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
Make sure to tell your healthcare provider about any other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.

Specific Precautions and Warnings With Ofirmev

Some warnings and precautions to be aware of prior to receiving this medicine include the following:
  • Ofirmev can damage the liver. Therefore, if you already have liver problems, you should talk to your healthcare provider before receiving Ofirmev.
  • People with alcoholism, kidney problems, chronic malnutrition, severe dehydration, or excessive blood loss may have an increased risk for liver damage due to Ofirmev.
  • Ofirmev contains acetaminophen. Acetaminophen is an active ingredient in many different prescription and nonprescription products, and it can be easy to overdose on acetaminophen if your healthcare provider is not very careful to calculate your total dosage of acetaminophen from all products (including Ofirmev). Make sure your healthcare provider knows if you take any other acetaminophen products.
  • Rarely, some people may have allergic reactions to Ofirmev. Notify your healthcare provider if you have any signs of a serious allergic reaction, such as:
    • An unexplained rash
    • Itching
    • Hives
    • Redness of the face
    • Swelling of the mouth or throat
    • Wheezing
    • Difficulty breathing.
  • Ofirmev is officially listed as a pregnancy Category C medication. This means that it may not be safe for use during pregnancy (see Ofirmev and Pregnancy). However, acetaminophen (the active ingredient in Ofirmev) is generally considered quite safe for use during pregnancy.
  • Ofirmev passes through breast milk. However, it is generally considered safe for breastfeeding women and their infants (see Ofirmev and Breastfeeding).
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Ofirmev Medication Information

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