Drug Interactions With Motrin (Cont.)

 
Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)
Using these pain relievers with Motrin can increase your risk of bleeding. Acetaminophen (Tylenol®) products can be used safely.
 
Aspirin
Studies have indicated that the chances are higher for developing stomach ulcers when aspirin and Motrin are combined. For your particular situation, talk to your healthcare provider about using aspirin and Motrin together.
 
ACE Inhibitors (Accupril, Lotensin, Vasotec, Altace, Zestril, Prinivil, Monopril, Capoten)
Motrin may inhibit the blood pressure-lowering effects of ACE inhibitors. Your healthcare provider may need to adjust your dose of these drugs.
 
Diuretics (Torsemide [Demadex], Furosemide [Lasix], Hydrochlorothiazide)
Motrin may reduce the activity of diuretics. Your healthcare provider may need to adjust your dose of these drugs.
 
Lithium (Eskalith, Lithane, Lithonate, Lithotabs)
Taking Motrin and lithium together may increase the levels of lithium in your body by decreasing the removal of lithium by the kidneys. Your healthcare provider may need to adjust your dose of these drugs and monitor the level of lithium in your blood.
 
Methotrexate (Rheumatrex, Trexall)
If you are taking both methotrexate and Motrin, your healthcare provider may monitor you more closely and may need to adjust your dose of these drugs.
 
Beta Blockers
Motrin may decrease the blood pressure-lowering effects of beta blockers. Your healthcare provider may need to adjust your dose of these drugs.
 
Corticosteroids
Using corticosteroids with Motrin can increase your risk of bleeding. Your healthcare provider may choose to monitor you more closely or adjust your dose of these drugs.
(Drug Interactions With Motrin Continued: Page 3)

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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;