Morphine Drug Interactions

Taking certain medications in combination with morphine may result in potentially dangerous complications. Some of these interactions can increase your risk of side effects, such as difficulty breathing, memory loss, and drowsiness. Alcohol, antihistamines, antipsychotic medications, and barbiturates are among the medications that can lead to drug interactions with morphine. To avoid any problems, make sure to talk to your healthcare provider before taking any medications (including non-prescription medications) with morphine.

Morphine Interactions: An Overview

Morphine can potentially interact with a number of other medications. Some of the medicines that may lead to drug interactions with morphine include, but are not limited to:
 
  • Alcoholic beverages (or other products that contain alcohol)
  • Alvimopan (Entereg®)
  • Antidepressant medications
  • Antihistamines (including many non-prescription cold, cough, allergy, motion sickness, and sleep medications)
  • Antipsychotics, including (but not limited to):

 

 

  • Barbiturates, such as:

 

    • Amobarbital (Amytal®)
    • Butalbital (Fioricet®, Fiorinal®)
    • Pentobarbital (Nembutal®)
    • Phenobarbital (Luminal®)
    • Secobarbital (Seconal®) 

 

  • Benzodiazepine sedatives, such as:

 

 

  • Muscle relaxants, such as:

 

 

  • Monoamine oxidase inhibitors (MAOIs), including:

 

 


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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;
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