Drug Interactions With Metaxalone

Several medications can cause drug interactions with metaxalone, so make sure to tell your healthcare provider about any other medicines you are taking before starting this muscle relaxant. Medications that may negatively interact with metaxalone include barbiturates, narcotics, and sleep medications. Some of these metaxalone drug interactions can increase the risk of side effects, such as drowsiness, confusion, or difficulty breathing.

An Overview of Drug Interactions With Metaxalone

Metaxalone (Skelaxin®) can potentially interact with several other medications. Some of the medicines that may lead to drug interactions with metaxalone include:
 
  • Alcohol
  • Barbiturates, such as:
 
    • Amobarbital (Amytal®)
    • Butalbital (Fioricet®, Fiorinal®)
    • Pentobarbital (Nembutal®)
    • Phenobarbital (Luminal®)
    • Secobarbital (Seconal®)
 
  • Benzodiazepines, such as:
 
 

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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;
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