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Drug Interactions With Meloxicam

Diuretics
Combining meloxicam with a diuretic can increase the risk of kidney problems, especially in people who already have kidney problems, and can decrease the effectiveness of the diuretic.
 
Lithium
Taking meloxicam and lithium together may increase the levels of lithium in your body by reducing the kidneys' ability to remove lithium. Your healthcare provider may need to adjust your dose of these drugs and monitor the level of lithium in your blood.
 
"Blood Thinners" and Other Similar Drugs
Combining meloxicam with anticoagulants ("blood thinners"), antiplatelet drugs, or other medications that increase the risk of bleeding may lead to serious bleeding problems, including dangerous internal bleeding. Do not combine meloxicam with such medications without your healthcare provider's approval and supervision.
 
Methotrexate
Meloxicam may increase the risk of methotrexate toxicity. Do not combine these medications without your healthcare provider's supervision and approval.
 
Probenecid
Probenecid may increase the level of meloxicam in the blood, increasing the risk of side effects. Check with your healthcare provider before taking these medications together.
 
Sodium Polystyrene Sulfonate
Combining sodium polystyrene sulfonate with sorbitol may increase the risk of intestinal necrosis (a potentially fatal problem of the digestive tract). Because meloxicam oral suspension (liquid) contains sorbitol, these medications should not be combined.
  
SSRIs or SNRIs
Combining a selective serotonin reuptake inhibitor (SSRI) or a serotonin-norepinephrine reuptake inhibitor (SNRI) with meloxicam may increase the risk of bleeding. Check with your healthcare provider before taking meloxicam with an SSRI or SNRI.
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