Drug Interactions With Mefenamic Acid

Mefenamic Acid Drug

Mefenamic Acid Interactions: An Overview

Mefenamic acid (Ponstel^®) can potentially interact with several different medicines. Some of the drugs that may lead to drug interactions with mefenamic acid include:

Warfarin (Coumadin^®, Jantoven^®)
Other nonsteroidal anti-inflammatory drugs (NSAIDs), such as:

Ibuprofen (Motrin^®, Advil^®)
Naproxen (Naprosyn^®)
Naproxen sodium (Aleve^®, Anaprox^®, Naprelan^®)
Diclofenac (Cataflam^®, Voltaren^®)
Indomethacin (Indocin^®)
Nabumetone (Relafen^®)
Oxaprozin (Daypro^®)
Celecoxib (Celebrex^®)
Meloxicam (Mobic^®)
Etodolac (Lodine^®)

Ketoprofen, ketorolac (Toradol^®)

Aspirin
Lithium (Eskalith^®, Lithane^®, Lithonate^®, Lithotabs^®)
Diuretics, such as torsemide (Demadex^®), furosemide (Lasix^®), or hydrochlorothiazide
ACE inhibitors, such as:

Ramipril (Altace^®)

Angiotensin II receptor blockers (ARBs), including:

Candesartan (Atacand^®)

Methotrexate (Rheumatrex^®, Trexall™)
Beta blockers, such as metoprolol (Lopressor^®, Toprol XL^®), propranolol (Inderal^®), and atenolol
Corticosteroids, such as prednisone, hydrocortisone (Cortef^®), dexamethasone (Decadron^®, Dexone^®, Hexadrol^®), and others
Cyclosporine (Gengraf^®, Neoral^®, Sandimmune^®)
Antacids, including Maalox^®, Mylanta^®, Riopan^®, Gelusil^®, and others.

Several herbal and nutritional supplements can also interact with mefenamic acid and may increase the risk of bleeding. Examples of these include but are not limited to:

Dong quai
Feverfew
Garlic
Ginger
Ginkgo biloba
Ginseng
St. John's wort
Fish oil supplements.

(Drug Interactions With Mefenamic Acid Continued: Page 2)