Drug Interactions With Mefenamic Acid

Medicines that can potentially lead to drug interactions with mefenamic acid include lithium, ACE inhibitors, corticosteroids, and certain herbal or nutritional supplements. Some of these drug interactions can cause side effects such as bleeding, stomach ulcers, or kidney damage, while others may lead to decreased effectiveness of the drugs or increased levels of mefenamic acid in your blood.

 

Drug Interactions With Mefenamic Acid: An Overview

Mefenamic acid (Ponstel®) has a number of medicines that it can potentially interact with. Some of the drugs that can interact with mefenamic acid include:
 

 

Several herbal and nutritional supplements can also interact with mefenamic acid and may increase the risk of bleeding. Examples of these include, but are not limited to:
 
Warfarin (Coumadin, Jantoven)
If you are taking other blood thinners, such as warfarin, while taking mefenamic acid, your body may metabolize them differently than intended. You healthcare provider may choose to monitor your INR and prothrombin time more frequently and adjust accordingly. INR and prothrombin time are tests used to measure how well your blood is clotting.
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;