Pain Home > Zipsor Side Effects

Abdominal pain, nausea, and headaches are the most common side effects that have been reported with Zipsor. In most cases, side effects of this medication do not require medical attention. However, certain side effects are potentially serious and should be reported to your healthcare provider, including chest pain, slurred speech, or bloody vomit.

An Introduction to Zipsor Side Effects

As with any medicine, side effects are possible with Zipsor™ (diclofenac potassium). However, not everyone who takes the medication will have problems. In fact, most people tolerate it quite well. If side effects do occur, in most cases, they are minor and either require no treatment or can easily be treated by you or your healthcare provider.
(This article covers many, but not all, of the possible side effects with Zipsor. Your healthcare provider can discuss a more complete list of Zipsor side effects with you.)

Common Side Effects of Zipsor

Zipsor has been studied thoroughly in clinical trials. In these studies, the side effects that occurred in a group of people taking Zipsor were documented and compared to side effects that occurred in another group of people using a placebo. This way, it is possible to see what Zipsor side effects occurred, how often they appeared, and how they compared to the placebo.
In these studies, the most common side effects of Zipsor included:
  • Nausea -- in up to 16.5 percent of people
  • Headache -- up to 12.5 percent
  • Abdominal pain (stomach pain) -- up to 7 percent
  • Vomiting -- up to 5.8 percent
  • Dizziness -- up to 3.5 percent
  • Constipation -- up to 3.2 percent.
Interestingly, most of these side effects actually occurred more frequently in people taking the placebo. This may be due to the fact that the study allowed patients to take opioid medications (morphine or other similar drugs) in addition to Zipsor or the placebo if more pain relief was necessary. As would be expected, people taking the placebo needed to use more opioids.
Other common side effects (occurring in 1 to 2.6 percent of people) included:
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
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