Pain Home > Tylenol with Codeine Drug Interactions

If you take antidepressants, sleep medications, or benzodiazepines in combination with Tylenol with Codeine, drug interactions could occur. These interactions may increase your risk of serious side effects, such as extreme drowsiness, confusion, memory loss, or difficulty breathing. To help reduce your chances of developing Tylenol with Codeine interactions, tell your healthcare provider about all other medications you are taking before using the pain reliever.

Tylenol with Codeine Interactions: An Overview

Tylenol® with Codeine (acetaminophen with codeine) can potentially interact with a number of other medications, particularly medications that tend to cause drowsiness or sedation. Some of the medicines that may lead to Tylenol with Codeine drug interactions include:
  • Alcoholic beverages
  • Antidepressants
  • Antihistamines (including many allergy, motion sickness, and sleep medications)
  • Antipsychotics
  • Barbiturate medications, including, but not limited to:


    • Butalbital (Fioricet®, Fiorinal®)
    • Pentobarbital (Nembutal®)
    • Phenobarbital (Luminal®)
    • Secobarbital (Seconal®)


  • Benzodiazepines, such as:



  • Other narcotics or opiates, such as morphine (MS Contin®, MSIR®) or oxycodone (OxyIR®, OxyContin®)
  • Other products that contain acetaminophen, including many prescription and non-prescription pain killers and cold or cough products
  • Sleep medications.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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