Pain Home > Tramadol Drug Interactions

Several medications can cause negative drug interactions with tramadol, including digoxin, sleep medications, and antipsychotic medications. These interactions could increase your risk of serious side effects, such as extreme drowsiness, memory loss, and difficulty breathing. To ensure a safe treatment process with tramadol, tell your healthcare provider about all other medications you are taking, including non-prescription medications.

Tramadol Interactions: An Overview

Tramadol hydrochloride (Ultram®) can potentially interact with a number of other medications. Some of the medicines that may lead to drug interactions with tramadol include:
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Last reviewed by: Kristi Monson, PharmD;
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