Pain Home > Tapentadol ER

Tapentadol ER is a medication prescribed for treating moderate-to-severe chronic pain in people who require around-the-clock pain relief. It is also approved for nerve pain associated with diabetic peripheral neuropathy. The medication comes in the form of extended-release tablets, and is taken every 12 hours. Because it is similar to morphine, it has the potential for dependence and abuse. Possible side effects include constipation, nausea, and dizziness.

What Is Tapentadol ER?

Tapentadol ER (Nucynta® ER) is an opiate pain reliever. It is a long-acting medication approved for use when continuous, around-the-clock pain control is needed for an extended period. It is approved to treat the following two types of pain:
  • Moderate-to-severe chronic pain
  • Nerve pain associated with diabetic peripheral neuropathy.
Tapentadol ER contains tapentadol, the first new molecule for pain relief to be developed within the past 25 years.
This drug is a narcotic and is a controlled substance in the United States.
(Click What Is Tapentadol ER Used For? for more information on this topic, including possible off-label uses.)

Are There Side Effects?

Just like any medicine, tapentadol ER may cause side effects. However, not everyone who takes the drug will experience problems. Most people tolerate it quite well. If reactions do occur, in most cases, they are minor and either require no treatment or are treated easily by you or your healthcare provider. Serious side effects are less common.
Common side effects of tapentadol ER include but are not limited to:
(Click Side Effects of Tapentadol ER to learn more, including potentially serious side effects you should report immediately to your healthcare provider.)
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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