Pain Home > Drug Interactions With Tapentadol ER

Several products can cause negative drug interactions with tapentadol ER, including alcohol, sleep medications, and antipsychotic medications. These reactions could increase your risk for serious side effects, such as extreme drowsiness, difficulty breathing, and memory loss. To ensure a safe treatment process with tapentadol ER, tell your healthcare provider about all other medications you are taking, including nonprescription medications and herbal supplements.

An Overview of Tapentadol ER Interactions

Tapentadol ER (Nucynta® ER) may react with a number of other medications. Some of the drugs that can lead to interactions with tapentadol ER include but are not limited to:
  • Alcohol
  • Anticholinergic medications, such as:
  • Linezolid (Zyvox®)
  • Medicines or substances likely to cause drowsiness, such as:
  • Monoamine oxidase inhibitors (MAOIs), such as:
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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