Pain Home > Drug Interactions With Tapentadol ER

Monoamine Oxidase Inhibitors (MAOIs)
Combining tapentadol ER with an MAOI can cause life-threatening reactions. Do not use tapentadol ER and an MAOI within 14 days of each other.
 
Short-Acting Tapentadol
Tapentadol ER should not be combined with short-acting tapentadol, as these medications have the same active ingredient. If a short-acting medication is needed for breakthrough pain, your healthcare provider should choose something other than short-acting tapentadol.
 
Sibutramine
Taking tapentadol ER with sibutramine can cause a group of symptoms called serotonin syndrome. Talk to your healthcare provider before taking these drugs together. Call your healthcare provider right away if you have any symptoms of serotonin syndrome, as it can be quite dangerous.
 
St. John's Wort
Taking tapentadol ER with St. John's wort can cause a group of symptoms called serotonin syndrome. Talk to your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any symptoms of serotonin syndrome, as it can be quite dangerous.
 
Tramadol
Taking tapentadol ER with tramadol can cause a group of symptoms called serotonin syndrome. Talk to your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any symptoms of serotonin syndrome, as it can be quite dangerous.
 
Triptans
Taking tapentadol ER with a triptan can cause a group of symptoms called serotonin syndrome. Talk to your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any symptoms of serotonin syndrome, as it can be quite dangerous.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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