Pain Home > Sumatriptan/Naproxen Sodium

Sumatriptan/naproxen sodium is a combination drug approved for treating migraine headaches. It contains sumatriptan, which works by narrowing the blood vessels in the head that become dilated during a migraine, and naproxen, which helps to relieve migraine pain by inhibiting the production of inflammatory chemicals. Sumatriptan/naproxen sodium comes in tablet form and should be taken as soon as possible once a migraine starts.

What Is Sumatriptan/Naproxen Sodium?

Sumatriptan/naproxen sodium (Treximet™) is a prescription medication that is used to treat migraine headaches. It will not help to prevent migraines but can help treat a migraine that is already occurring. Sumatriptan/naproxen sodium contains two different medications to help relieve migraine pain.
(Click What Is Sumatriptan/Naproxen Sodium Used For? for more information on sumatriptan/naproxen sodium uses, including possible off-label uses.)

Sumatriptan/Naproxen Sodium Side Effects

As with any medicine, sumatriptan/naproxen sodium can cause side effects. However, not everyone who uses the medication will experience side effects. In fact, most people tolerate it quite well. If side effects do occur, in most cases, they are minor and either require no treatment or can easily be treated by you or your healthcare provider. Serious side effects are less common.
Common side effects of sumatriptan/naproxen sodium include, but are not limited to:
  • Dizziness
  • Drowsiness
  • Nausea
  • Chest, neck, or jaw pain.
(Click Side Effects of Sumatriptan/Naproxen Sodium to learn more, including potentially serious side effects that you should report immediately to your healthcare provider.)
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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