Pain Home > Subsys Warnings and Precautions
People who are using Subsys for treating breakthrough cancer pain should be aware that this medication can cause serious complications, such as a slow heart rate and potentially life-threatening breathing problems. Other safety precautions with Subsys involve warnings about using this drug while pregnant or breastfeeding. In addition, it can cause negative interactions with alcohol and a number of medications.
What Should I Tell My Healthcare Provider?Talk with your healthcare provider prior to using Subsys® (fentanyl sublingual spray) if you have:
- A history of drug or alcohol dependence or abuse
- Liver disease, such as cirrhosis, liver failure, or hepatitis
- Kidney disease, such as kidney failure (renal failure)
- A history of breathing problems, asthma, chronic obstructive lung disease (COPD), or other lung disease
- A head injury, brain tumor, or increased pressure around the brain
- Ever had a seizure
- A slow heart rate or other heart problems
- Low blood pressure (hypotension)
- Any allergies, including to foods, dyes, or preservatives.
- Pregnant or thinking of becoming pregnant.