Pain Home > Subsys Drug Interactions

There are many drugs that may cause potentially serious interactions with Subsys. Problems may occur if the opioid narcotic medication is taken with products such as alcohol, amphetamines, or sleep medicines. Some of these combinations may increase your risk for side effects or decrease the effectiveness of the medications. Your healthcare provider may need to monitor you more closely and adjust your dosages.

An Overview of Interactions With Subsys

Subsys® (fentanyl sublingual spray) is a prescription narcotic pain medication used to treat breakthrough pain in people with cancer. This product may potentially react with many other medications.
 
Some of the drugs that may lead to Subsys interactions include but are not limited to:
 
  • Alcohol
  • Alvimopan (Entereg®)
  • Amphetamines or amphetamine-like medications, such as:
 
 
 
 
 
 
  • CYP 3A4 inducer medications, such as:
 
 
  • CYP 3A4 inhibitor medications, such as:
 
 
  • Desmopressin (DDAVP®, Minirin®, Stimate®)
  • Grapefruit juice
  • Medications that cause drowsiness, such as:
 
 
  • Monoamine oxidase inhibitors (MAOIs), such as:

 

 
  • Octreotide (Sandostatin®)
  • Pegvisomant (Somavert®)
  • Thiazide diuretics (and thiazide-like diuretics), such as:
 
 
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
List of references (click here):
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