Pain Home > Sprix Drug Interactions

Lithium
Using Sprix in combination with lithium reduces the ability to remove lithium from the body, thereby increasing lithium levels. If you take these medications together, make sure to watch for signs of lithium toxicity, such as weakness, tremors, excessive thirst, and confusion.
 
Your healthcare provider may choose to monitor your lithium levels while you are using Sprix and may need to adjust your dose.
 
Medications That "Thin" the Blood
Medications that have anticoagulant, antiplatelet, or thrombolytic effects may increase the risk of bleeding with Sprix. Always check with your healthcare provider before combining Sprix with any blood-thinning medication.
 
Methotrexate
Using Sprix in combination with methotrexate may increase your risk for methotrexate toxicity. If you are taking methotrexate, talk to your healthcare provider about using these medications together before starting treatment with Sprix.
 
Pentoxifylline
Combining Sprix with pentoxifylline may increase the risk of bleeding. These medications should not be used together. If you are taking pentoxifylline, talk with your healthcare provider before using Sprix.
 
Probenecid
Using Sprix in combination with probenecid can increase the levels of Sprix in your body, increasing your risk of serious side effects. These medications should not be used together. If you are taking probenecid, talk with your healthcare provider prior to using Sprix.
 
Psychoactive Drugs
There have been rare cases of hallucinations (seeing, hearing, or sensing something that is not real) in people taking psychoactive drugs with ketorolac, the active ingredient in Sprix. If you are taking psychoactive drugs, make sure to talk to your healthcare provider before using Sprix.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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