Pain Home > Relafen Drug Interactions

There are many potential Relafen drug interactions to be aware of. For example, Relafen can interact with other nonsteroidal anti-inflammatory drugs like ibuprofen and oxaprozin -- as well as with corticosteroids and herbal or nutritional supplements -- to increase your risk of bleeding. Relafen drug interactions can also reduce the effectiveness of ACE inhibitors and diuretics. Kidney damage and an increased risk of stomach ulcers can also result from drug interactions with Relafen.

Relafen Drug Interactions: An Introduction

Relafen® (nabumetone) can potentially interact with a number of medicines. Some of these Relafen drug interactions include:
 
 
  • Angiotensin II receptor blockers (ARBs), such as:

 

 
 
 
  • Corticosteroids, including (but not limited to):
     
    • Betamethasone (Celestone®)
    • Cortisone
    • Dexamethasone (Decadron®)
    • Fludrocortisone (Florinef®)
    • Hydrocortisone (Cortef®)
    • Methylprednisolone (Depo-Medrol®, Medrol®)
    • Prednisolone (Orapred®, Pediapred®)
    • Prednisone
    • Triamcinolone (Kenalog®, Aristospan®)
 
 
 
 
 
      • Alteplase (Activase®)
      • Reteplase (Retavase®)
      • Streptokinase (Streptase®)
      • Tenecteplase (TNKase®)
 
 
 
Several herbal and nutritional supplements can also interact with Relafen and may increase the risk of bleeding. Examples of these include, but are not limited to:
 
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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