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How Does Pregabalin Work?

It is not known exactly how pregabalin works to prevent partial seizures in people with epilepsy. Additionally, it is not known exactly how pregabalin works for nerve pain or fibromyalgia. It is known that pregabalin binds to certain parts of calcium channels in the central nervous system, and this may be how pregabalin works for seizures, nerve pain, and anxiety. Although pregabalin is not approved for anxiety treatment, it has anti-anxiety properties and may be an effective anxiety medication.

Pregabalin Uses in Children

Pregabalin is not approved to treat nerve pain, fibromyalgia, or epilepsy in children. Talk with your healthcare provider about the benefits and risks of using pregabalin in children.

Off-Label Pregabalin Uses

On occasion, your healthcare provider may recommend pregabalin for something other than the conditions discussed above. This is known as using the medicine for "off-label" purposes. At this time, off-label pregabalin uses can include the treatment of:
  • Anxiety
  • Moderate pain, such as after a dental procedure.
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Last reviewed by: Kristi Monson, PharmD;
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