Pain Home > Drug Interactions With Pegloticase
Theoretically, it may be possible for pegloticase to react with certain "PEGylated" medications, such as Adagen, Doxil, and Somavert. However, no studies have been done to determine specific drug interactions with pegloticase. Even though no specific interactions are known, make sure your healthcare provider is aware of any other medications you are taking, including nonprescription medicines.
An Overview of Pegloticase InteractionsPegloticase (Krystexxa®) is a prescription gout medication that is given intravenously (by IV). No drug-interaction studies have been done with pegloticase.
However, it is theoretically possible that pegloticase might possibly interact with "PEGylated" medications (drug molecules that have been attached to polyethylene glycol polymers). PEGylated medications include:
- Adagen® (pegademase bovine)
- Cimzia® (certolizumab pegol)
- Doxil® (liposomal doxorubicin)
- Macugen® (pegaptanib)
- Neulasta® (pegfilgrastim)
- Oncaspar® (pegaspargase)
- Pegasys® (peginterferon alfa-2a)
- PegIntron® (peginterferon alfa-2b)
- Somavert® (pegvisomant).
Pegloticase often stimulates the body to produce a certain type of antibody that might bind to other PEGylated medications. It is unknown what effect (if any) this might have on other PEGylated medications.