Pain Home > Oxycodone/APAP

Oxycodone/APAP is a combination medication used to treat moderate to moderately severe pain. The drug is available in tablets, capsules, and as an oral solution. It is typically taken as needed for pain, although some healthcare providers recommend that it be taken every six hours. Strict rules regulate the sale and use of oxycodone/APAP, as it is a highly abused drug. Possible side effects include constipation, drowsiness, and nausea.

What Is Oxycodone/APAP?

Oxycodone/APAP (Endocet®, Magnacet™, Percocet®, Roxicet™, Tylox®) is a prescription medication approved to treat moderate to moderately severe pain. None of the oxycodone/APAP products available are appropriate for severe pain.
All oxycodone/APAP products are narcotics and are classified as Schedule II controlled substances in the United States. This means that special laws and regulations control their sale and use. Of all legal prescription medications, Schedule II controlled substances have the highest abuse potential.
(Click What Is Oxycodone/APAP Used For? for more information, including possible off-label uses.)

Oxycodone/APAP Side Effects

Just like any medicine, oxycodone/APAP can cause side effects. However, not everyone who takes the drug will experience side effects. If they do occur, in most cases, side effects are minor and either require no treatment or are easily treated by you or your healthcare provider. Serious side effects are less common.
Common side effects of oxycodone/APAP include but are not limited to:
  • Nausea
  • Vomiting
  • Constipation
  • Lightheadedness
  • Dizziness
  • Drowsiness
  • Itching
  • An unexplained, pleasant feeling (euphoria) or an unexplained, unpleasant feeling (dysphoria).
(Click Side Effects of Oxycodone/APAP to learn more, including potentially serious side effects you should report immediately to your healthcare provider.)
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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