Pain Home > Opana ER

As a type of opioid narcotic medicine, Opana ER is prescribed for continuous, around-the-clock pain relief. This extended-release tablet is usually taken twice a day, with about 12 hours between doses. The drug has a high potential for both physical and psychological dependence and abuse. Side effects may include constipation, vomiting, and drowsiness.

What Is Opana ER?

Opana® ER (oxymorphone ER) is a long-acting prescription pain medication. It should be used only when around-the-clock use of strong painkillers is necessary for an extended period of time (for more than a few days).
(Click Opana ER Uses for more information on this topic, including possible off-label uses.)

Who Makes This Medication?

Opana ER is made by Pharmaceutical Manufacturing Research Services, Inc., for Endo Pharmaceuticals, Inc.

How Does Opana ER Work?

Opana ER tablets are specially designed to release oxymorphone over an extended period of time. As a result, you can take Opana ER just twice a day, rather than taking short-acting oxymorphone (Opana®) many times a day.
Oxymorphone is an opioid narcotic medication that is chemically related to morphine. It binds to opioid receptors throughout the body and produces numerous effects, including but not limited to:
  • Pain relief
  • Drowsiness
  • Slowing of the digestive tract
  • Cough suppression
  • Release of histamine (which often causes itching)
  • Unusual unpleasant feelings (dysphoria) or unusual pleasant feelings (euphoria)
  • Decreased breathing (slow or shallow breathing)
  • Certain changes in the circulatory system
  • Physical dependence.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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