Pain Home > Nucynta Side Effects

In clinical studies, the most common side effects reported with Nucynta included drowsiness, nausea, and dizziness. Serious reactions may also occur while taking this pain reliever. Tell a healthcare provider right away if you experience hallucinations, severe constipation, or any signs of serotonin syndrome (such as confusion or a rapid heart rate).

An Introduction to Nucynta Side Effects

Just like any medicine, Nucynta™ (tapentadol) can cause side effects. However, not everyone who takes the medication will have problems. In fact, some people tolerate it quite well. If side effects do occur, in many cases, they are minor and either require no treatment or are treated easily by you or your healthcare provider.
 
(This article covers many, but not all, of the possible side effects with Nucynta. Your healthcare provider can discuss a more complete list with you.)
 

Common Side Effects of Nucynta

Nucynta has been studied thoroughly in clinical trials. In these studies, one group of people received the real medication, while another group was given a placebo (a "sugar pill" with no active ingredients). As a result, it is possible to see what Nucynta side effects occurred, how often they appeared, and how they compared to the group not taking the medicine.
 
In these studies, the most common adverse reactions to Nucynta included:
 
  • Nausea -- in up to 30 percent of people
  • Dizziness -- up to 24 percent
  • Vomiting -- up to 18 percent
  • Drowsiness -- up to 15 percent
  • Constipation -- up to 8 percent
  • Itching -- up to 5 percent.
     
Other common side effects (occurring in 1 to 4 percent of people) included:
 
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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