Pain Home > Drug Interactions With Motrin

Medicines such as ACE inhibitors or diuretics may cause drug interactions with Motrin. These interactions can decrease the effectiveness of the drugs or cause certain side effects, including stomach ulcers or severe bleeding. Other medications that may potentially cause drug interactions with Motrin include corticosteroids, methotrexate, and aspirin.

Drug Interactions With Motrin: An Overview

Motrin® (ibuprofen) has a number of medicines that it can potentially interact with. Some of these drug interactions with Motrin include:


Several herbal and nutritional supplements can also interact with Motrin and may increase the risk of bleeding. Examples of these include, but are not limited to:
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Last reviewed by: Kristi Monson, PharmD;
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