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More Detail on Indocin Interactions

The following sections explain in detail the potentially negative interactions that can occur if Indocin is combined with any of the substances listed above.
 
ACE Inhibitors
Combining Indocin with an ACE inhibitor can increase the risk of kidney problems, especially in people who already have kidney problems, and can decrease the effectiveness of the ACE inhibitor for lowering blood pressure.
 
ARBs
Combining Indocin with an ARB can increase the risk of kidney problems, especially in people who already have kidney problems, and can decrease the effectiveness of the ARB for lowering blood pressure.
 
Beta Blockers
Combining Indocin with a beta blocker may interfere with the beta blocker's ability to lower blood pressure. Check with your healthcare provider before taking these medications together.
 
Bile Acid Sequestrants
Bile acid sequestrants can bind to Indocin in the digestive tract and delay its absorption into the body. To avoid this drug interaction, Indocin should be taken at least one hour before or four to six hours after the bile acid sequestrant has been taken.
 
Corticosteroids
Using corticosteroids with Indocin can increase the risk of bleeding. Your healthcare provider may choose to monitor you more closely or adjust your dose of these drugs.
 
Cyclosporine
Indocin may increase the level of cyclosporine in the blood, increasing the risk of serious cyclosporine side effects. In addition, this combination may increase the risk of kidney damage. Check with your healthcare provider before taking these medications together.
 
Digoxin
Indocin may increase the level of digoxin in your bloodstream, increasing the risk of dangerous digoxin side effects. If you are taking digoxin, check with your healthcare provider before starting or stopping Indocin.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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