Pain Home > Duragesic Drug Interactions

Duragesic may react with amphetamines, beta blockers, anxiety medications, and various other drugs. Interactions may still occur even though Duragesic comes in the form of a skin patch, as some of the medication is absorbed into the bloodstream. Interactions with the patch may also lead to various side effects or increase the risk of serious complications, such as dangerously low blood pressure or difficulty breathing.

An Overview of Interactions With Duragesic

Even though Duragesic® (fentanyl patch) is a patch that is applied to the skin, it can potentially interact with several other medications (since some of the medication is absorbed into the bloodstream).
Some of the medications that may lead to Duragesic drug interactions include but are not limited to:
  • Alcohol
  • Alvimopan (Entereg®)
  • Amphetamines or amphetamine-like medications, such as:
  • CYP 3A4 inducer medications, such as:
  • Desmopressin (DDAVP®, Minirin®, Stimate®)
  • Grapefruit juice
  • Medications that cause drowsiness, such as:
  • Monoamine oxidase inhibitors (MAOIs), such as:
  • Octreotide (Sandostatin®)
  • Pegvisomant (Somavert®)
  • Thiazide diuretics (and thiazide-like diuretics), such as:
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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