Pain Home > Diflunisal

Diflunisal, which is available by prescription, is commonly used to treat conditions related to pain, inflammation, and stiffness. Some of these conditions include symptoms of osteoarthritis and rheumatoid arthritis, as well as pain related to bone, muscle, or tendon injury. The medication comes in tablet form and is usually taken twice a day. Common side effects include nausea, diarrhea, and headache.

What Is Diflunisal?

Diflunisal (Dolobid®) is a prescription medicine used for mild to moderate pain relief, as well as inflammation and stiffness caused by osteoarthritis or rheumatoid arthritis. Diflunisal is in a class of drugs called nonsteroidal anti-inflammatory drugs, or NSAIDs for short.
(Click What Is Diflunisal Used For? for more information on these uses, including possible off-label uses for the drug.)

Who Makes It?

Brand-name Dolobid was manufactured by Merck & Co., but is no longer being made. Generic versions are still available.

How Does It Work?

Diflunisal and other NSAIDs are thought to work by inhibiting the action of certain hormones that cause inflammation and pain in the body. These hormones are called prostaglandins.

Effects of Diflunisal

By blocking prostaglandins, diflunisal is useful at reducing pain related to bone, muscle, or tendon injury or inflammation, as well as alleviating pain and joint swelling associated with different types of arthritis. Diflunisal is not a cure for arthritis, however, nor does it affect the progression of the disease.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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