Pain Home > Diclofenac/Misoprostol

Some people who have certain types of arthritis may find that diclofenac/misoprostol is an effective medicine. This combination medication works in two ways: by treating the symptoms of arthritis and by preventing ulcers that can occur from the pain-relieving component. Diclofenac/misoprostol comes in tablet form and is taken two to four times daily. Indigestion, diarrhea, and nausea are possible side effects.

What Is Diclofenac/Misoprostol?

Diclofenac/misoprostol (Arthrotec®) is a combination prescription medication approved to treat the symptoms of certain types of arthritis in people who are at risk for peptic ulcers from the use of nonsteroidal anti-inflammatory drugs (NSAIDs). It contains diclofenac sodium (Voltaren®, Voltaren®-XR), an NSAID that is used to relieve the symptoms of arthritis, and misoprostol (Cytotec®), a prostaglandin that helps reduce the risk of ulcers.
(Click What Is Diclofenac/Misoprostol Used For? for more information on this topic, including possible off-label uses.)

Are There Side Effects?

Just like any medicine, diclofenac/misoprostol may cause side effects. However, not everyone who takes the drug will experience problems. In fact, most people tolerate it quite well.
If reactions do occur, in most cases, they are minor and either require no treatment or are treated easily by you or your healthcare provider. Serious side effects are less common.
Common side effects of diclofenac/misoprostol include but are not limited to:
(Click Diclofenac/Misoprostol Side Effects to learn more, including potentially serious side effects you should report immediately to your healthcare provider.)
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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