Combining Darvon with any medication that causes drowsiness can increase your risk of side effects, such as drowsiness, confusion, memory loss, or difficulty breathing. Other serious side effects, such as dangerously low blood pressure, may also occur. Talk to your healthcare provider before taking Darvon with such medications.
Additionally, combining Darvon with antidepressants may increase the risk of a group of symptoms called serotonin syndrome. These symptoms include confusion, hallucinations, a fast heartbeat, feeling faint, fever, sweating, muscle spasms, difficulty walking, and diarrhea. Talk to your healthcare provider before taking Darvon with an antidepressant. Call your healthcare provider right away if you have any of these symptoms, as serotonin syndrome can be very dangerous.
Monoamine Oxidase Inhibitors (MAOIs)
As mentioned previously, combining Darvon with antidepressants (including MAOIs) can increase the risk of serotonin syndrome. Due to the high risk of this problem with MAOIs, it is usually recommended that Darvon not be combined with an MAOI. Do not take Darvon and an MAOI within 14 days of each other.
There have been reports of a possible interaction between Darvon and warfarin. This interaction might increase your risk of bleeding. Check with your healthcare provider before combining these medications; you may need to be monitored more closely.
It is possible that not all Darvon drug interactions were discussed in this article. Therefore, you should talk with your pharmacist or healthcare provider about any specific drug interactions that may apply to you.
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Food and Drug Administration, Center for Drug Evaluation and Research. Propoxyphene: Withdrawal -- Risk of Cardiac Toxicity (11/19/2010). FDA Web site. Available at: http://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm234389.htm. November 19, 2010.
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