Pain Home > Drug Interactions With Celecoxib

An increased risk of stomach ulcers, increased drug levels in the blood, and decreased effectiveness of certain medications can all occur when celecoxib is taken with other medications. Celecoxib may interact with aspirin, fluconazole, and lithium. If you are experiencing celecoxib drug interactions, your healthcare provider may adjust your dosages or monitor you more closely.

Interactions With Celecoxib: An Overview

Celecoxib (Celebrex®) can potentially interact with a number of medications. Medicines that can cause celecoxib drug interactions include:
 
 
  • Angiotensin II receptor blockers (ARBs), such as:

 

 
 
 
  • Corticosteroids, including (but not limited to):
     
    • Betamethasone (Celestone®)
    • Cortisone
    • Dexamethasone (Decadron®)
    • Fludrocortisone (Florinef®)
    • Hydrocortisone (Cortef®)
    • Methylprednisolone (Depo-Medrol®, Medrol®)
    • Prednisolone (Orapred®, Pediapred®)
    • Prednisone
    • Triamcinolone (Kenalog®, Aristospan®)
 
 
 
 
 
      • Alteplase (Activase®)
      • Reteplase (Retavase®)
      • Streptokinase (Streptase®)
      • Tenecteplase (TNKase®)
 
 
 
Several herbal and nutritional supplements can also interact with celecoxib and may increase the risk of bleeding. Examples of these include, but are not limited to:
 
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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