Pain Home > Drug Interactions With Acetaminophen

Some of the medications that may cause acetaminophen drug interactions include warfarin, carbamazepine, cholestyramine, and barbiturates. These interactions may affect the way your body handles acetaminophen, which can make both drugs less effective and more toxic. If you take other products that contain acetaminophen, you should not take more than 4000 mg total of the drug per day.

(In November 2010, the United States Food and Drug Administration approved an intravenous form of acetaminophen. For information on this product, see Ofirmev.)
 

Acetaminophen Interactions: An Overview

Acetaminophen (Tylenol®) can potentially interact with other medications. Some of the medicines that may lead to drug interactions with acetaminophen include:
 
  • Alcohol
  • Barbiturates, such as:
 
    • Amobarbital (Amytal®)
    • Butalbital (Fioricet®, Fiorinal®)
    • Pentobarbital (Nembutal®)
    • Phenobarbital (Luminal®)
    • Secobarbital (Seconal®)
 
 
 
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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