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Lortab Drug Interactions

When antidepressants, barbiturates, or alcoholic beverages are taken together with Lortab, drug interactions may occur. Combining these products with the pain reliever could increase your risk of serious side effects, such as drowsiness, confusion, memory loss, or difficulty breathing. To help prevent Lortab interactions, be sure to tell your healthcare provider about all other medications you are taking.

Lortab Interactions: An Overview

Lortab® (hydrocodone/APAP) can potentially interact with a number of other medications. Some of the medicines that may lead to Lortab drug interactions include:
  • Acetaminophen products, including many prescription and non-prescription pain killers and cold or cough products
  • Alcoholic beverages
  • Antidepressants
  • Antihistamines (often used for allergies, sleep, or motion sickness)
  • Antipsychotic medications, such as:



  • Barbiturates, such as:


    • Amobarbital (Amytal®)
    • Butalbital (Fioricet®, Fiorinal®)
    • Pentobarbital (Nembutal®)
    • Phenobarbital (Luminal®)
    • Secobarbital (Seconal®)


  • Benzodiazepines, such as:



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Lortab Medication Information

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