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Lortab Drug Interactions

Lortab Drug Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when Lortab is combined with any of the drugs listed above.
Acetaminophen Products
When taking Lortab, you should limit your total daily dose of acetaminophen (from all sources combined) to no more than 4 grams (4000 mg) per day. The acetaminophen content of Lortab is 500 mg per tablet or per tablespoonful (15 mL) for Lortab Elixir. Taking too much acetaminophen could lead to serious liver damage or even death.
Watch for any other sources of acetaminophen, including other prescription pain relievers and many over-the-counter products, such as Tylenol®. To be safe, all other acetaminophen products should be avoided while you are taking Lortab, unless you are extremely careful to limit your total acetaminophen use (from all sources added together) to 4 grams per day.
Alcoholic Beverages
You should avoid alcohol while taking Lortab. Alcohol interacts with the narcotic component of Lortab (hydrocodone), potentially increasing the risk of serious side effects, such as extreme drowsiness, confusion, memory loss, or difficulty breathing. Alcohol also interacts with the acetaminophen (Tylenol) component of Lortab, increasing the risk of liver damage (see Tylenol and Alcohol for more information).
Antidepressant Medications
Combining an antidepressant with Lortab could increase your risk of side effects, such as drowsiness, confusion, memory loss, or difficulty breathing. Serious side effects may also occur. Talk to your healthcare provider before taking Lortab with an antidepressant, as you may need to be monitored more closely, and the dose of your medications may need to be adjusted.
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Lortab Medication Information

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