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Lorcet Drug Interactions

If you combine alcohol or antidepressants with Lorcet, drug interactions may occur. These interactions could increase your risk of serious side effects, such as drowsiness, confusion, memory loss, or difficulty breathing. Other medications that may lead to potentially serious drug interactions with Lorcet include antihistamines, other acetaminophen products, sleep medicines, and benzodiazepines.

Lorcet Drug Interactions: An Overview

Lorcet® (hydrocodone/APAP) can potentially interact with a number of other medications. Some of the medicines that may lead to Lorcet interactions include:
  • Alcohol
  • Antidepressants of any kind
  • Antihistamines (including many allergy, sleep, and motion sickness medications)
  • Antipsychotic medications
  • Barbiturates, including (but not limited to):


    • Butalbital (Fioricet®, Fiorinal®)
    • Pentobarbital (Nembutal®)
    • Phenobarbital (Luminal®)
    • Secobarbital (Seconal®)


  • Benzodiazepines, such as:



  • Other acetaminophen products, including many prescription and non-prescription pain killers and cold or cough products
  • Other narcotics or opiates, such as morphine (MSContin®, MSIR®) or oxycodone (OxyIR®, OxyContin®)
  • Sleep medications.
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Lorcet Plus Information

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