Lodine Drug Interactions

When medicines such as phenylbutazone or warfarin are taken with Lodine, it is possible for drug interactions to occur. These interactions can increase the risk of stomach ulcers, bleeding problems, or kidney damage, among other things. Other drugs that can interact with Lodine include cyclosporine, diuretics, and herbal or nutritional supplements. If these interactions are a concern, your healthcare provider may adjust your dosages or monitor you more closely.

Lodine (Etodolac)

Lodine Interactions: An Introduction

Lodine^® (etodolac) can potentially interact with a number of other medicines. Some of these medications include:

Warfarin (Coumadin^®, Jantoven^®)
Other nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen (Advil^®, Motrin^®), naproxen (Aleve^®, Anaprox^®, Naprosyn^®, Naprelan^®), diclofenac (Cataflam^®, Voltaren^®), indomethacin (Indocin^®), nabumetone (Relafen^®), oxaprozin (Daypro^®), celecoxib (Celebrex^®), and meloxicam (Mobic^®)
Aspirin
Lithium (Eskalith^®, Lithane^®, Lithonate^®, Lithotabs^®)
Diuretics, such as torsemide (Demadex^®), furosemide (Lasix^®), and hydrochlorothiazide
ACE inhibitors, such as quinapril (Accupril^®), benazepril (Lotensin^®), enalapril (Vasotec^®), and ramipril (Altace^®)
Methotrexate (Rheumatrex^®, Trexall™)
Cyclosporine (Gengraf^®, Neoral^®, Sandimmune^®)
Digoxin (Digitek^®, Lanoxin^®, Lanoxicap^®)
Phenylbutazone
Corticosteroids, such as prednisone, hydrocortisone (Cortef^®), and dexamethasone (Decadron^®, Dexone^®, Hexadrol^®).

Several herbal and nutritional supplements can also interact with Lodine and may potentially increase the risk of bleeding. Examples of these include, but are not limited to:

Dong quai
Feverfew
Garlic
Ginger
Ginkgo biloba
Ginseng
St. John's wort
Fish oil supplements.

(Lodine Drug Interactions Continued: Page 2)