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Lodine Drug Interactions

When medicines such as warfarin are taken with Lodine, it is possible for drug interactions to occur. These interactions can increase the risk of stomach ulcers, bleeding problems, or kidney damage, among other things. Other drugs that can interact with Lodine include cyclosporine, diuretics, and herbal or nutritional supplements. If these interactions are a concern, your healthcare provider may adjust your dosages or monitor you more closely.

Lodine Interactions: An Introduction

Lodine® (etodolac) can potentially interact with a number of other medicines. Some of these medications include:
  • Angiotensin II receptor blockers (ARBs), such as:


  • Corticosteroids, including (but not limited to):
    • Betamethasone (Celestone®)
    • Cortisone
    • Dexamethasone (Decadron®)
    • Fludrocortisone (Florinef®)
    • Hydrocortisone (Cortef®)
    • Methylprednisolone (Depo-Medrol®, Medrol®)
    • Prednisolone (Orapred®, Pediapred®)
    • Prednisone
    • Triamcinolone (Kenalog®, Aristospan®)


      • Alteplase (Activase®)
      • Reteplase (Retavase®)
      • Streptokinase (Streptase®)
      • Tenecteplase (TNKase®)
Several herbal and nutritional supplements can also interact with Lodine and may potentially increase the risk of bleeding. Examples of these include, but are not limited to:
Alternative Therapies for Pain Management

Lodine (Etodolac)

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