Lodine Drug Interactions (Cont.)

More Information on Lodine Interactions

The following sections explain in detail how the drugs mentioned above can cause negative interactions when combined with Lodine.
 
Warfarin
If you are taking blood thinners, such as warfarin, while taking Lodine, your body may metabolize them differently than intended. Your healthcare provider may choose to monitor your INR and prothrombin time more frequently and adjust your dosages accordingly. INR and prothrombin time are tests used to measure how well your blood is clotting.
 
Nonsteroidal Anti-Inflammatory Drugs
Using these pain relievers with Lodine can increase the risk for bleeding. However, acetaminophen (Tylenol®) products can be safely used.
 
Aspirin
Aspirin and Lodine can be used together; however, studies have indicated that the chances for stomach ulcers are higher when these medicines are combined. Talk to your healthcare provider about using aspirin and Lodine together in your particular situation.
 
ACE Inhibitors
Lodine may inhibit the blood pressure-lowering effects of ACE inhibitors. As a result, your healthcare provider may need to adjust your dose of these drugs.
 
Diuretics
Lodine may reduce the activity of diuretics. Your healthcare provider may need to adjust your dose of these drugs to prevent this interaction from occurring.
 
Lithium
Taking Lodine and lithium together may increase the levels of lithium in your body by decreasing the amount removed by the kidneys. Your healthcare provider may need to adjust your dose of these drugs and monitor the level of lithium in your blood to avoid this interaction.
(Lodine Drug Interactions Continued: Page 3)

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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;