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Drug Interactions

Leflunomide may react with a number of other medicines (see Drug Interactions With Leflunomide).

What If I Overdose on This Medicine?

An overdose with this medication could be potentially dangerous. If you take too much leflunomide, seek immediate medical attention.
(Click Arava Overdose for more information.)

What Should I Do If I Forget a Dose of Leflunomide?

If you happen to forget a dose of leflunomide, take your missed dose as soon as you remember. If it is almost time for your next dose, however, skip the missed dose and continue with your regular schedule. Do not take a double dose.

How Does It Work?

Leflunomide belongs to a class of medications called disease-modifying antirheumatic drugs (DMARDs). DMARDs are a group of drugs that work in different ways to slow down the progression of rheumatoid arthritis.
Leflunomide works by blocking the body's ability to make molecules called pyrimidines. T cells are a type of immune cell known to be overactive in people with rheumatoid arthritis. They produce chemicals that cause inflammation and damage joint tissue. T cells need pyrimidines to divide, or reproduce. By inhibiting pyrimidine production, leflunomide prevents T cells from reproducing, thereby reducing inflammation and preventing joint damage.
DMARDs, including leflunomide, are not intended to provide immediate relief from symptoms. Therefore, they may be used with medicines that can relieve ongoing symptoms, such as nonsteroidal anti-inflammatory drugs (NSAIDs) or low doses of prednisone.
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Leflunomide Drug Information

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