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Drug Interactions With Leflunomide

More Detail on Drug Interactions With Leflunomide

The following sections explain in detail the potentially negative reactions that can occur when leflunomide is combined with any of the drugs listed above.
 
Bile Acid Sequestrants
Taking bile acid sequestrants with leflunomide will decrease the amount of leflunomide in your blood, making it less effective. You should generally avoid taking these medications together, unless your healthcare provider tells you otherwise. Cholestyramine (a bile acid sequestrant) is used to decrease the amount of leflunomide in the blood when quick removal of the medicine from the body is necessary, such as in the case of a leflunomide overdose.
 
Methotrexate
Combining leflunomide with methotrexate may increase your risk for potentially serious side effects, such as liver problems. Your healthcare provider will need to monitor you more closely if you take these medications together.
 
Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)
Leflunomide may increase the level of NSAIDs in your bloodstream, potentially increasing your risk for NSAID side effects. If you take these medications together, your healthcare provider may choose to monitor you more closely, and may decrease your NSAID dose if needed.
 
Immunosuppressants
Leflunomide is an immunosuppressant, which means it suppresses the immune system. Taking it with other immunosuppressant medications can increase your risk for potentially serious side effects. Talk to your healthcare provider before taking leflunomide with another immunosuppressant medication.
 
Rifampin
Rifampin can increase leflunomide blood levels, which may increase your risk for potentially serious leflunomide side effects. Leflunomide and rifampin should only be used together with caution. If you take rifampin with leflunomide, your healthcare provider will need to monitor you closely.
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