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Ketoprofen Precautions and Warnings

Some Ketoprofen Precautions and Warnings

Some ketoprofen warnings and precautions to be aware of include the following:
  • There are certain other medications with which ketoprofen can interact (see Ketoprofen Drug Interactions).
  • All NSAIDs, including ketoprofen, have been reported to cause cardiovascular events such as heart attack or stroke, which can result in loss of life. People with cardiovascular disease or who have cardiovascular risk factors appear to be at greater risk. To decrease your chances of experiencing such problems, take the smallest effective dose for the shortest period of time. Call 911 if you notice things such as chest pain, shortness of breath, weakness, and slurring of speech.
  • Ketoprofen, like other NSAIDs, may cause or worsen high blood pressure. If you have high blood pressure, make sure your healthcare provider is aware of it. He or she will likely wish to use particular caution when prescribing ketoprofen in your case.
  • All NSAIDs, including ketoprofen, may cause congestive heart failure or swelling. Contact your healthcare provider if you notice unexplained weight gain or swelling. Also, ketoprofen should be used with caution in people with heart failure.
  • All NSAIDs, including ketoprofen, can cause problems in the stomach and intestines, including bleeding (known as gastrointestinal bleeding), stomach ulcers, or holes in the stomach or intestines. These problems can lead to serious complications or even loss of life. If you have a history of ulcers or gastrointestinal bleeding, it's extremely important that you tell your healthcare provider before taking ketoprofen. He or she will likely need to use extreme caution when prescribing ketoprofen in your case. To decrease the chances of stomach or intestinal problems occurring, take the smallest effective dose for the shortest period of time. Contact your healthcare provider immediately if you experience any signs or symptoms of stomach ulcers or bleeding, including:
o Abdominal pain (or stomach pain)
o Indigestion
o Black, tarry stools
o Vomiting blood.
  • Kidney damage can occur in people taking NSAIDs, including ketoprofen. It is more common in people with kidney disease, heart failure, or liver problems; those taking diuretics or ACE inhibitor medication; and the elderly.
  • Liver damage can occur in people who are using ketoprofen. Contact your healthcare provider immediately if you notice things such as nausea, tiredness, lethargy, itchy or yellowing skin, abdominal pain (or stomach pain), or flu-like symptoms.
  • NSAIDs, including ketoprofen, can cause allergic reactions. Seek emergency medical attention immediately if you notice things such as difficulty breathing or swelling of the face and throat.
  • In rare cases, people taking ketoprofen can develop a very serious rash. If you notice an unexplained rash or blisters, fever, or itchy skin, stop taking the ketoprofen and call your healthcare provider.
  • If you are an alcoholic or drink alcohol frequently, discuss this with your healthcare provider prior to starting ketoprofen. Alcohol can affect the way the liver works, indirectly affecting the ketoprofen.
  • NSAIDs such as ketoprofen have been known to cause an increase in liver enzymes. Therefore, your healthcare provider may recommend that you have a blood test that assesses your liver function before starting ketoprofen and 12 weeks after treatment has started.
  • Ketoprofen can cause anemia. If you are taking ketoprofen for an extended period of time and show signs of anemia, talk to your healthcare provider.
  • Do not take ketoprofen with any other NSAIDs, as this may increase your risk for any of the problems discussed above. There are many NSAIDs available with or without a prescription. Make sure to read labels carefully. Some examples of NSAIDs include ibuprofen (Motrin®, Advil®), naproxen (Aleve®, Anaprox®, Naprosyn®, Naprelan®), celecoxib (Celebrex®), etodolac (Lodine®, Lodine XL), diclofenac (Cataflam®, Voltaren®), and meloxicam (Mobic®). You can ask your doctor or pharmacist for a complete list of these medications.
  • Ketoprofen is a pregnancy Category C medicine, meaning that it could potentially cause harm to a fetus. If you are pregnant, you should only take ketoprofen if your healthcare provider feels that the benefit outweighs the possible risk to your unborn child. Women in the third trimester should not take ketoprofen because it may cause injury and even death to the developing fetus. If you become pregnant while taking ketoprofen, contact your healthcare provider immediately (see Ketoprofen and Pregnancy for more information).
  • If you are nursing, you should not take ketoprofen. In the event that you are taking ketoprofen and nursing, ask your healthcare provider about whether you should stop nursing or discontinue the medicine.
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