When medications such as aspirin or diuretics are taken with ketoprofen, drug interactions may occur. Ketoprofen drug interactions may also occur with medications such as ibuprofen, warfarin, lithium, and corticosteroids. While some drug interactions can cause one or both drugs to lose its effectiveness, others may cause bleeding, kidney damage, stomach ulcers, or other serious side effects.
Corticosteroids, such as prednisone, hydrocortisone (Cortef®), dexamethasone (Decadron®, Dexone®, Hexadrol®), and many others.
Several herbal and nutritional supplements can also interact with ketoprofen and may increase the risk of bleeding. Examples of these include, but are not limited to: