Ketoprofen Drug Interactions

When medications such as aspirin or diuretics are taken with ketoprofen, drug interactions may occur. Ketoprofen drug interactions may also occur with medications such as ibuprofen, warfarin, lithium, and corticosteroids. While some drug interactions can cause one or both drugs to lose its effectiveness, others may cause bleeding, kidney damage, stomach ulcers, or other serious side effects.

What Is Ketoprofen?

Ketoprofen Drug Interactions: An Introduction

Ketoprofen has a number of medicines with which it may interact. Some ketoprofen drug interactions involve medications such as:

Other nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen (Advil^®, Motrin^®), naproxen (Aleve^®, Anaprox^®, Naprosyn^®, Naprelan^®), diclofenac (Cataflam^®, Voltaren^®), indomethacin (Indocin^®), oxaprozin (Daypro^®), celecoxib (Celebrex^®), etodolac (Lodine^®, Lodine XL), meloxicam (Mobic^®), and others
Aspirin

Warfarin (Coumadin^®, Jantoven^®)

Lithium (Eskalith^®, Lithane^®, Lithonate^®, Lithotabs^®)
Diuretics, such as torsemide (Demadex^®), furosemide (Lasix^®), and hydrochlorothiazide
Angiotensin-converting enzyme inhibitors (ACE inhibitors) such as lisinopril (Zestril^®, Prinivil^®), fosinopril (Monopril^®), captopril (Capoten^®), quinapril (Accupril^®), benazepril (Lotensin^®), enalapril (Vasotec^®), and ramipril (Altace^®)
Methotrexate (Rheumatrex^®, Trexall™)
Cyclosporine (Gengraf^®, Neoral^®, Sandimmune^®)
Probenecid (Benemid^®, Probalan^®)
Corticosteroids, such as prednisone, hydrocortisone (Cortef^®), dexamethasone (Decadron^®, Dexone^®, Hexadrol^®), and many others.

Several herbal and nutritional supplements can also interact with ketoprofen and may increase the risk of bleeding. Examples of these include, but are not limited to:

Dong quai
Feverfew
Garlic
Ginger
Ginkgo biloba
Ginseng
St. John's wort
Fish oil supplements.

(Ketoprofen Drug Interactions Continued: Page 2)