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Ketoprofen Drug Interactions

Digoxin
Ketoprofen may increase the level of digoxin in your bloodstream, increasing the risk of dangerous digoxin side effects. If you are taking digoxin, check with your healthcare provider before starting or stopping ketoprofen.
 
Diuretics
Combining ketoprofen with a diuretic can increase the risk of kidney problems, especially in people who already have kidney problems, and can decrease the effectiveness of the diuretic.
 
Lithium
Taking ketoprofen and lithium together may increase the levels of lithium in your body by reducing the kidneys' ability to remove lithium. Your healthcare provider may need to adjust your dose of these drugs and monitor the level of lithium in your blood.
 
"Blood Thinners" and Other Similar Drugs
Combining ketoprofen with anticoagulants ("blood thinners"), antiplatelet drugs, or other medications that increase the risk of bleeding may lead to serious bleeding problems, including dangerous internal bleeding. Do not combine ketoprofen with such medications without your healthcare provider's approval and supervision.
 
Methotrexate
Ketoprofen may increase the risk of methotrexate toxicity. Do not combine these medications without your healthcare provider's supervision and approval.
 
Probenecid
Probenecid may increase the level of ketoprofen in the blood, increasing the risk of side effects. Check with your healthcare provider before taking these medications together.
 
SSRIs or SNRIs
Combining a selective serotonin reuptake inhibitor (SSRI) or a serotonin-norepinephrine reuptake inhibitor (SNRI) with ketoprofen may increase the risk of bleeding. Check with your healthcare provider before taking ketoprofen with an SSRI or SNRI.
 
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