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Drug Interactions With Ketamine

When barbiturates, narcotic pain relievers, or other drugs are combined with ketamine, negative interactions could occur. These reactions may decrease the effectiveness of the anesthetic or increase your risk for side effects. To minimize any complications, make sure your healthcare provider is aware of any prescription or nonprescription medications you are taking, as well as any vitamins or supplements.

An Overview of Ketamine Interactions

Ketamine hydrochloride (Ketalar®) may potentially react with a number of other medications. Some of the drugs that may lead to interactions with ketamine include but are not limited to:
  • Barbiturates, such as:
    • Amobarbital (Amytal®)
    • Butalbital (Fioricet®, Fiorinal®)
    • Pentobarbital (Nembutal®)
    • Phenobarbital (Luminal®)
    • Secobarbital (Seconal®)
  • CYP 2B6 inhibitor medications, such as:
  • CYP 2C9 inducer medications, such as:
  • CYP 2C9 inhibitor medications, such as:


  • CYP 3A4 inhibitor medications, such as:




Alternative Therapies for Pain Management

Ketamine Drug Information

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