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Drug Interactions With Ketamine

More Detail on Drug Interactions With Ketamine

The following sections explain in detail the potentially negative reactions that can occur when ketamine is combined with any of the drugs listed above.
 
Barbiturates
It may take longer for you to recover from anesthesia if you take a barbiturate with ketamine. Talk to your healthcare provider about this potential interaction before your medical procedure.
 
CYP 2B6 Inhibitor Medications
The liver breaks down ketamine using enzymes known as CYP 2B6 enzymes. Medications known as CYP 2B6 inhibitors can decrease the activity of these enzymes. Combining ketamine with one of these CYP 2B6 inhibitors may increase the level of ketamine in your body. Your healthcare provider may need to monitor your response to ketamine more closely if you take it with a CYP 2B6 inhibitor.
 
CYP 2C9 Inducer Medications
The liver breaks down ketamine using enzymes known as CYP 2C9 enzymes. Medications known as CYP 2C9 inducers can increase the activity of these enzymes. Combining ketamine with one of these CYP 2C9 inducers may decrease the level of ketamine in your body, potentially making it less effective. Your healthcare provider may need to monitor you more closely if you take ketamine with a CYP 2C9 inducer.
 
CYP 2C9 Inhibitor Medications
The liver breaks down ketamine using enzymes known as CYP 2C9 enzymes. Medications known as CYP 2C9 inhibitors can decrease the activity of these enzymes. Combining ketamine with one of these CYP 2C9 inhibitors may increase the level of ketamine in your body. Your healthcare provider may need to monitor your response to ketamine more closely if you take a CYP 2C9 inhibitor.
 
CYP 3A4 Inhibitor Medications
The liver breaks down ketamine using enzymes known as CYP 3A4 enzymes. Medications known as CYP 3A4 inhibitors can decrease the activity of these enzymes. Combining ketamine with one of these CYP 3A4 inhibitors may increase the level of ketamine in your body. Your healthcare provider may monitor you more closely if you take ketamine with a CYP 3A4 inhibitor.
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