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Indocin Side Effects

Based on the results of clinical studies, side effects of Indocin most commonly include headache, heartburn or indigestion, nausea, and dizziness. Serious problems may include major or life-threatening bleeding. Seek medical attention if you notice unusual bleeding, vomit blood, or experience blood in the urine or stools.

An Overview of Indocin Side Effects

As with any medicine, side effects are possible with Indocin® (indomethacin). However, not everyone who takes the drug will experience problems. In fact, most people tolerate it well. If side effects do occur, they are generally minor and either require no treatment or can be treated easily by you or a healthcare provider.
(This article discusses many, but not all, of the possible side effects of Indocin. Your healthcare provider can discuss a more complete list with you.)

Common Side Effects of Indocin

Indocin has been studied extensively in clinical trials, with thousands of people worldwide having been evaluated. In these studies, side effects are always documented and compared to those that occur in a similar group of people not taking the medicine. This way, it is possible to see what side effects occur, how often they appear, and how they compare to the group not taking the medicine.
Based on the results of these studies, the most common Indocin side effects (occurring in more than 3 percent of people) included:
  • Headache
  • Heartburn or indigestion (dyspepsia)
  • Nausea, with or without vomiting
  • Dizziness.
Other reactions, occurring in more than 1 percent of people, included:
  • Diarrhea
  • Abdominal pain (stomach pain)
  • Constipation
  • Spinning sensation (vertigo)
  • Excessive tiredness
  • Depression
  • Fatigue
  • Ringing in the ears (tinnitus).
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Indocin Medication

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