Potential Indocin drug interactions may occur involving medications such as warfarin, lithium, cyclosporine, and methotrexate. In addition, taking other nonsteroidal anti-inflammatory drugs with Indocin can result can lead to potentially dangerous drug interactions. When certain medicines are taken together with Indocin, drug interactions may increase the risk of developing serious health problems, such as major bleeding, stomach ulcers, and kidney damage.
Indocin® (indomethacin) has a number of medicines with which it may interact. Some of these potential Indocin drug interactions involve medications such as:
Corticosteroids, such as prednisone, hydrocortisone (Cortef®), dexamethasone (Decadron®, Dexone®, Hexadrol®), and many others
Probenecid (Benemid®, Probalan®).
Several herbal and nutritional supplements can also interact with Indocin and may increase the risk of bleeding. Examples of these include (but are not limited to):