Indocin Drug Interactions

Potential Indocin drug interactions may occur involving medications such as warfarin, lithium, cyclosporine, and methotrexate. In addition, taking other nonsteroidal anti-inflammatory drugs with Indocin can result can lead to potentially dangerous drug interactions. When certain medicines are taken together with Indocin, drug interactions may increase the risk of developing serious health problems, such as major bleeding, stomach ulcers, and kidney damage.

Indocin Medication

Indocin Drug Interactions: An Introduction

Indocin^® (indomethacin) has a number of medicines with which it may interact. Some of these potential Indocin drug interactions involve medications such as:

Other nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen (Advil^®, Motrin^®), naproxen (Aleve^®, Anaprox^®, Naprosyn^®, Naprelan^®), diclofenac (Cataflam^®, Voltaren^®), oxaprozin (Daypro^®), celecoxib (Celebrex^®), etodolac (Lodine^®, Lodine XL), meloxicam (Mobic^®), and others
Warfarin (Coumadin^®, Jantoven^®)

Aspirin
Lithium (Eskalith^®, Lithane^®, Lithonate^®, Lithotabs^®)
Diuretics, such as torsemide (Demadex^®), furosemide (Lasix^®), hydrochlorothiazide
Angiotensin-converting enzyme inhibitors (ACE inhibitors) such as lisinopril (Zestril^®, Prinivil^®), fosinopril (Monopril^®), captopril (Capoten^®), quinapril (Accupril^®), benazepril (Lotensin^®), enalapril (Vasotec^®), and ramipril (Altace^®)
Beta blockers, such as metoprolol (Lopressor^®), propranolol (Inderal^®), atenolol (Tenormin^®), and metoprolol (Toprol XL^®)
Methotrexate (Rheumatrex^®, Trexall™)
Cyclosporine (Gengraf^®, Neoral^®, Sandimmune^®)
Diflunisal (Dolobid^®)
Corticosteroids, such as prednisone, hydrocortisone (Cortef^®), dexamethasone (Decadron^®, Dexone^®, Hexadrol^®), and many others
Probenecid (Benemid^®, Probalan^®).

Several herbal and nutritional supplements can also interact with Indocin and may increase the risk of bleeding. Examples of these include (but are not limited to):

Dong quai
Feverfew
Garlic
Ginger
Ginkgo biloba
Ginseng
St. John's wort
Fish oil supplements.

(Indocin Drug Interactions Continued: Page 2)