Hydrocodone/APAP Drug Interactions

Several medications can cause dangerous drug interactions with hydrocodone/APAP, including alcohol, sleep medications, and barbiturates. These interactions could increase your risk of serious side effects, such as extreme drowsiness and difficulty breathing. One of the most important hydrocodone/APAP drug interactions to avoid involves other acetaminophen products. To be safe, such products should be avoided while you are taking hydrocodone/APAP.

Drug Interactions With Hydrocodone/APAP: An Overview

Hydrocodone/APAP (hydrocodone and acetaminophen) can potentially interact with several different medications. Some of the medicines that may lead to hydrocodone/APAP drug interactions include:
 
  • Alcohol
  • Antidepressants
  • Antihistamines
  • Antipsychotic medications
  • Barbiturates, such as:
     
    • Amobarbital (Amytal®)
    • Butalbital (Fioricet®, Fiorinal®)
    • Pentobarbital (Nembutal®)
    • Phenobarbital (Luminal®)
    • Secobarbital (Seconal®)
 
 
  • Other acetaminophen products, including many prescription and non-prescription pain killers and cold or cough products
  • Other narcotics or opiates, such as morphine (MS Contin®, MSIR®) or oxycodone (OyxIR®, OxyContin®)
  • Sleep medications.
     

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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;
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