Hydrocodone/APAP Drug Interactions
Several medications can cause dangerous drug interactions with hydrocodone/APAP, including alcohol, sleep medications, and barbiturates. These interactions could increase your risk of serious side effects, such as extreme drowsiness and difficulty breathing. One of the most important hydrocodone/APAP drug interactions to avoid involves other acetaminophen products. To be safe, such products should be avoided while you are taking hydrocodone/APAP.
Drug Interactions With Hydrocodone/APAP: An OverviewHydrocodone/APAP (hydrocodone and acetaminophen) can potentially interact with several different medications. Some of the medicines that may lead to hydrocodone/APAP drug interactions include:
- Antipsychotic medications
- Barbiturates, such as:
- Amobarbital (Amytal®)
- Butalbital (Fioricet®, Fiorinal®)
- Pentobarbital (Nembutal®)
- Phenobarbital (Luminal®)
- Secobarbital (Seconal®)
- Benzodiazepines, such as:
- Other acetaminophen products, including many prescription and non-prescription pain killers and cold or cough products
- Other narcotics or opiates, such as morphine (MS Contin®, MSIR®) or oxycodone (OxyIR®, OxyContin®)
- Sleep medications.